GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs661242 | chr11:71579229 | FAM86C | chr11:71498557-71512276:+ | -0.31 | -3.97 | 8.4E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs6494537 | 1 | rs662099 | chr15:65726693 | DPP8 | chr15:65737999-65810035:- | -0.1 | -4.13 | 4.21E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs662099 | chr15:65726693 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.84 | 0.00014 | Mean corpuscular hemoglobin |
| THCA | cis | rs683250 | 1 | rs662545 | chr11:83267886 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 4.09 | 5.15E-5 | Subcortical brain region volumes |
| THCA | cis | rs237743 | 1 | rs6648 | chr20:47895242 | DDX27 | chr20:47835832-47860612:+ | 0.25 | 4.6 | 5.31E-6 | Height |
| THCA | cis | rs11825709 | 1 | rs66480929 | chr11:93696650 | HEPHL1 | chr11:93754378-93847374:+ | 0.56 | 4.59 | 5.71E-6 | Obesity-related traits |
| THCA | cis | rs4332428 | 1 | rs6650153 | chr10:5019320 | AKR1C2 | chr10:4964715-5060207:- | 0.4 | 5.29 | 1.86E-7 | Height |
| THCA | cis | rs7818688 | 1 | rs6651271 | chr8:96047621 | C8orf38 | chr8:95908040-96088396:+ | -0.27 | -4.61 | 5.09E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs7818688 | 1 | rs6651272 | chr8:96047933 | C8orf38 | chr8:95908040-96088396:+ | 0.27 | 4.61 | 5.09E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs775227 | 1 | rs66518523 | chr3:113004759 | SIDT1 | chr3:113251218-113348421:+ | 0.2 | 3.35 | 0.000858 | Dental caries |
| THCA | cis | rs12304921 | 1 | rs66518563 | chr12:51358252 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.83 | 1.87E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs66518563 | chr12:51358252 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.28 | 2.25E-5 | Type 2 diabetes |
| THCA | cis | rs12107539 | 1 | rs66524723 | chr3:151037061 | GPR87 | chr3:151011876-151034636:- | 0.21 | 4.64 | 4.5E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs66524723 | chr3:151037061 | P2RY14 | chr3:150929905-150996230:- | -0.2 | -4.31 | 2.02E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs11734488 | 1 | rs66528719 | chr4:139122577 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.53 | 7.48E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |